John J Renger Selected Research

Orexin Receptors

1/2017	The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia.
1/2016	Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain.
11/2015	Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
6/2015	Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
1/2014	Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs.
7/2012	International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology.
4/2010	Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists.
3/2010	Orexin receptor antagonists: a review of promising compounds patented since 2006.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

John J Renger Research Topics

Disease

28	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2017 - 08/2007
8	Schizophrenia (Dementia Praecox) 01/2016 - 11/2010
7	Alzheimer Disease (Alzheimer's Disease) 10/2015 - 09/2010
5	Parkinson Disease (Parkinson's Disease) 01/2021 - 10/2008
4	Narcolepsy 01/2017 - 01/2012
4	Weight Gain 01/2016 - 06/2009
3	Disorders of Excessive Somnolence (Hypersomnia) 01/2017 - 01/2012
3	Pain (Aches) 01/2016 - 11/2010
3	Epilepsy (Aura) 02/2014 - 05/2010
3	Sleep Wake Disorders 02/2014 - 03/2010
2	AIDS-Related Complex (ARC) 01/2018 - 04/2013
2	Sleep Deprivation 01/2018 - 06/2011
2	Panic Disorder (Panic Attack) 01/2017 - 09/2015
2	Hypersensitivity (Allergy) 01/2016 - 02/2013
2	Hyperalgesia 01/2016 - 02/2013
2	Catalepsy 12/2015 - 09/2012
2	Sleepiness 09/2014 - 11/2013
2	Cataplexy 01/2014 - 07/2012
2	Body Weight (Weight, Body) 01/2014 - 06/2009
2	Obesity 01/2014 - 06/2009
2	Mental Disorders (Mental Disorder) 07/2012 - 03/2010
2	Mood Disorders (Mood Disorder) 07/2012 - 10/2011
1	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/2021
1	Memory Disorders (Memory Loss) 01/2019
1	Disease Progression 01/2017
1	Neuralgia (Stump Neuralgia) 01/2016
1	Tauopathies 10/2015
1	Anxiety Disorders (Anxiety Disorder) 09/2015
1	Hypertension (High Blood Pressure) 02/2014
1	Neoplasms (Cancer) 02/2014
1	Hyperinsulinism (Hyperinsulinemia) 01/2014
1	Insulin Resistance 01/2014
1	Cognitive Dysfunction 04/2013
1	Cocaine-Related Disorders (Cocaine Addiction) 03/2013
1	Unconsciousness (Loss of Consciousness) 08/2012

Drug/Important Bio-Agent (IBA)

18	OrexinsIBA 01/2019 - 07/2009
15	Orexin Receptor AntagonistsIBA 01/2017 - 01/2010
8	Orexin ReceptorsIBA 01/2017 - 03/2010
6	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2016 - 09/2012
6	T-Type Calcium Channels (T-Type Calcium Channel)IBA 02/2014 - 06/2009
4	suvorexantIBA 01/2017 - 03/2011
4	Amyloid (Amyloid Fibrils)IBA 02/2014 - 09/2010
3	Peptides (Polypeptides)IBA 01/2016 - 02/2014
3	Biological ProductsIBA 02/2015 - 07/2010
3	Zolpidem (Ambien)FDA LinkGeneric 11/2013 - 11/2007
2	EnzymesIBA 01/2021 - 09/2010
2	Antidepressive Agents (Antidepressants)IBA 01/2018 - 10/2011
2	Phosphotransferases (Kinase)IBA 01/2017 - 01/2016
2	ProlactinIBA 01/2016 - 09/2012
2	Haloperidol (Haldol)FDA LinkGeneric 12/2015 - 09/2012
2	NeuropeptidesIBA 09/2014 - 03/2012
2	Protein Isoforms (Isoforms)IBA 01/2014 - 02/2013
2	Antipsychotic Agents (Antipsychotics)IBA 01/2014 - 09/2012
2	Histamine (Histamine Dihydrochloride)FDA Link 12/2013 - 06/2011
2	Modafinil (Provigil)FDA Link 12/2013 - 06/2011
2	Eszopiclone (Lunesta)FDA Link 11/2013 - 04/2013
2	DORA-22IBA 11/2013 - 04/2013
2	2- (4- cyclopropylphenyl)- N- (1- (5- ((2,2,2- trifluoroethyl)oxo)pyridin- 2- yl)ethyl)acetamideIBA 02/2013 - 06/2009
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	Tamsulosin (Flomax)FDA LinkGeneric 01/2021
1	Doxazosin (Cardura)FDA LinkGeneric 01/2021
1	Adrenergic Antagonists (Antiadrenergic Agents)IBA 01/2021
1	Terazosin (Hytrin)FDA LinkGeneric 01/2021
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2021
1	alfuzosin (UroXatral)FDA Link 01/2021
1	NexusIBA 01/2018
1	Pharmaceutical PreparationsIBA 01/2017
1	Designer DrugsIBA 01/2017
1	Freund's AdjuvantIBA 01/2016
1	dual orexin receptor antagonist 12IBA 01/2016
1	Leucine (L-Leucine)FDA Link 01/2016
1	Formaldehyde (Formol)FDA Link 01/2016
1	AmidesIBA 11/2015
1	tau Proteins (tau Protein)IBA 10/2015
1	Hypnotics and Sedatives (Sedatives)IBA 09/2015
1	BenzodiazepinesIBA 09/2015
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 06/2015
1	Donepezil (Aricept)FDA LinkGeneric 06/2015
1	GABA Receptors (GABA Receptor)IBA 09/2014
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2014
1	FatsIBA 01/2014
1	SugarsIBA 01/2014
1	2- (6- chloropyridin- 3- yl)- 4- (1- methoxypropan- 2- yl)oxy- N- (6- methylpyridin- 3- yl)- 7,8- dihydropyrido(4,3- d)pyrimidine- 6(5H)- carboxamideIBA 01/2014
1	ClusterinIBA 01/2014
1	MK-7288IBA 12/2013
1	Aminobutyrates (Aminobutyric Acid)IBA 04/2013
1	activity regulated cytoskeletal-associated proteinIBA 04/2013
1	ElementsIBA 03/2013
1	Analgesics (Analgesic Drugs)IBA 02/2013
1	gamma-Aminobutyric Acid (GABA)IBA 01/2013
1	GABA-A Receptors (GABA(A) Receptor)IBA 01/2013
1	Ethanol (Ethyl Alcohol)IBA 01/2013
1	Olanzapine (Zyprexa)FDA Link 09/2012
1	General AnestheticsIBA 08/2012
1	NeurotensinIBA 07/2012
1	LigandsIBA 07/2012

Therapy/Procedure

7	Therapeutics 01/2021 - 04/2010
1	Ligation 01/2016
1	Oral Administration 02/2013
1	Hypnosis (Mesmerism) 08/2012